The garden was founded on October 17, 1755, by King Ferdinand VI, and installed in the Orchard of Migas Calientes, near what today is called Puerta de Hierro, on the banks of the Manzanares River. It contained more than 2,000 plants collected by José Quer y Martínez, botanist and surgeon. In 1774 King Charles III ordered the garden moved to its current location on the Paseo del Prado, with design by architects Francesco Sabatini and Juan de Villanueva that organized the garden into three tiered terraces, arranging plants according to the method of Linnaeus. This new site opened in 1781.
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